PUBLICATION
Optogenetic control of mRNA condensation reveals an intimate link between condensate material properties and functions
Lee M, Moon HC, Jeong H, Kim DW, Park HY#, Shin Y# (2024)
Nature Communications
Thermodynamic modulation of gephyrin condensation by inhibitory synapse components
Lee G, Kim S, Hwang DE, Eom YG, Jang G, Park HY, Choi JM#, Ko J#, Shin Y# (2024)
Proceedings of the National Academy of Sciences (PNAS)
Disruption of G-quadruplex dynamicity by BRCA2 abrogation instigates phase separation and break-induced replication at telomeres
Lee JJ, Kim H, Park H, Lee U, Kim C, Lee M, Shin Y, Jung JJ, Lee HB, Han W, Lee H (2024)
Nucleic Acids Research
Intrinsically disordered region-mediated condensation of IFN-inducible SCOTIN/SHISA-5 inhibits ER-to-Golgi vesicle transport
Kim N, Kim,TH, Kim C, Lee JE, Kang MG, Shin S, Jung M, Kim JS, Mun JY, Rhee HW, Park SY, Shin Y, Yoo JY (2023)
Developmental Cell
Molecular basis for SOX2-dependent regulation of super-enhancer activity
Yoo W, Song YW, Kim J, Ahn J, Kim J, Shin Y, Ryu JK, Kim KK (2023)
Nucleic Acids Research
RNA-mediated demixing transition of low-density condensates
Kim T, Yoo J, Do S, Hwang DS, Park Y, Shin Y# (2023)
Nature Communications
Probabilistic establishment of speckle-associated inter-chromosomal interactions
Joo J, Cho S, Hong S, Min S, Kim K, Kumar R, Choi JM, Shin Y#, Jung I# (2023)
Nucleic Acids Research
Engineering DNA-based synthetic condensates with programmable material properties, compositions, and functionalities
Do S, Lee C, Lee T, Kim DN#, Shin Y# (2022)
Science Advances
Formation of non-base-pairing DNA microgels using directed phase transition of amphiphilic monomers
Lee C, Do S, Lee JY, Kim M, Kim SM, Shin Y#, Kim DN# (2022)
Nucleic Acids Research
Rich phase separation behavior of biomolecules
Shin Y# (2022)
Molecules and Cells
The flexibility-based modulation of DNA nanostar phase separation
Lee T, Do S, Lee JG, Kim DN, Shin Y# (2021)
Nanoscale
Featured as "Nanoscale Most Popular 2021 Articles"
Label‐free quantitative analysis of Coacervates via 3D phase imaging
Hong Y, Dao KP, Kim T, Lee S, Shin Y, Park Y, Hwang DS (2021)
Advanced Optical Materials
High-throughput injection molded microfluidic device for single-cell analysis of spatiotemporal dynamics
Kim Y, Song J, Lee Y, Cho S, Kim S, Lee SR, Park S, Shin Y#, Jeon NL# (2021)
Lab on a Chip
Nucleated transcriptional condensates amplify gene expression
Wei M, Chang Y, Shimobayashi SF, Shin Y, Strom AR and Brangwynne CP (2020)
Nature Cell Biology
Liquid nuclear condensates mechanically sense and restructure the genome
Shin Y*, Chang Y*, Lee DSW, Berry J, Sanders DW, Ronceray P, Wingreen NS, Haataja MP and Brangwynne CP (2018)
Cell
Featured in Cell "Preview Mechanobiology of Protein Droplets: Force Arises from Disorder"
Featured as "Technologies to watch in 2020" in Nature
Featured as Research Highlight "Optogenetic tools light up phase separation" in Nature Methods
Liquid phase condensation in cell physiology and disease
Shin Y and Brangwynne CP (2017)
Science
Spatio-temporal control of intracellular phase transitions using light-activated optoDroplets
Shin Y, Berry J, Pannucci N, Haataja MP, Toettcher JE and Brangwynne CP (2017)
Cell
Featured in Cell "Preview Shining a Light on Phase Separation in the Cell"
Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus-end by a kinesin-8
Shin Y*, Du Y*, Collier SE, Ohi MD, Lang MJ and Ohi R (2015)
Proceedings of the National Academy of Science USA
Stochastic but highly coordinated protein unfolding and translocation by the ClpXP proteolytic machine
Cordova JC*, Olivares AO*, Shin Y*, Stinson BM, Calmat S, Schmitz KR, Aubin-Tam M, Baker TA, Lang MJ, and Sauer RT (2014)
Cell
Kinesin-12 Kif15 targets kinetochore fibers through an intrinsic two-step mechanism
Sturgill EG, Das DK, Takizawa Y, Shin Y, Collier S, Ohi MD, Hwang W, Lang MJ, and Ohi R (2014)
Current Biology
Stochastic Optical Active Rheology
Lee H, Shin Y, Kim ST, Reinherz EL and Lang MJ (2012)
Applied Physics Letters
TCR mechanobiology: Torques and tunable structures linked to early T cell signaling
Kim ST, Shin Y, Brazin K, Mallis RJ, Sun J, Wagner G, Lang MJ and Reinherz EL (2012)
Frontiers in Immunology
Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease
Shin Y*, Davis JH*, Brau RR*, Martin A*, Kenniston JA, Baker TA, Sauer RT, and Lang MJ (2009)
Proceedings of the National Academy of Science USA
(* equal contribution)